MTA-ELTE Immunológiai Kutatócsoport
Vezető: Erdei Anna

MTA-ELTE Lendület Komplement Kutatócsoport
Vezető: Józsi Mihály Krisztián

 
Hírek
  • 2017.09.08-12

    A Koppenhágában lezajlott konferencián (16th European Meeting of Complement in Human Disease) két doktoranduszunk, Lukácsi Szilvi (poszter kategóra) és Kárpáti Évi (absztrakt kategóra) díjban részesültek.

    Gratulálunk!!!

  • Új cikkeink 
    • Pozsgay J, Szekanecz Z, Sármay G. Antigen-specific immunotherapies in rheumatic diseases.Nat Rev Rheumatol. 2017 Sep;13(9):525-537. doi: 10.1038/nrrheum.2017.107. Epub 2017 Jul 13. Review. PMID: 28701761

    • Bankó Z, Pozsgay J, Gáti T, Rojkovich B, Ujfalussy I, Sármay G.Regulatory B cells in rheumatoid arthritis: Alterations in patients receiving anti-TNF therapy.Clin Immunol. 2017 May 12. pii: S1521-6616(16)30560-5. doi: 10.1016/j.clim.2017.05.012. [Epub ahead of print] PMID: 28506920

    • Tóth EA, Oszvald Á, Péter M, Balogh G, Osteikoetxea-Molnár A, Bozó T, Szabó-Meleg E, Nyitrai M, Derényi I, Kellermayer M, Yamaji T, Hanada K, Vígh L, Matkó J. Nanotubes connecting B lymphocytes: High impact of differentiation-dependent lipid composition on their growth and mechanics. Biochim Biophys Acta - Molecular and Cell Biology of Lipids 1862 (2017) 991–1000

    • Goodship TH, Cook HT, Fakhouri F, Fervenza FC, Frémeaux-Bacchi V, Kavanagh D, Nester CM, Noris M, Pickering MC, Rodríguez de Córdoba S, Roumenina LT, Sethi S, Smith RJ; Conference Participants. Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference. Kidney Int. 2017 Mar;91(3):539-551.

    • Trojnár E, Józsi M, Uray K, Csuka D, Szilágyi Á, Milosevic D, Stojanović VD, Spasojević B, Rusai K, Müller T, Arbeiter K, Kelen K, Szabó AJ, Reusz GS, Hyvärinen S, Jokiranta TS, Prohászka Z. Analysis of Linear Antibody Epitopes on Factor H and CFHR1 Using Sera of Patients with Autoimmune Atypical Hemolytic Uremic Syndrome. Front Immunol. 2017 Mar 30;8:302.

    • Józsi M. Factor H family proteins in complement evasion of microorganisms. Front Immunol. 2017 May 18;8:571.

    • Csincsi ÁI, Szabó Z, Bánlaki Z, Uzonyi B, Cserhalmi M, Kárpáti É, Tortajada A, Caesar JJE, Prohászka Z, Jokiranta TS, Lea SM, Rodríguez de Córdoba S, Józsi M. FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation. J Immunol. 2017 May 22. pii: 1600483. doi: 10.4049/jimmunol.1600483. [Epub ahead of print]

    • Vaeth M, Yang J, Yamashita M, Zee I, Eckstein M, Knosp C, Kaufmann U, Karoly Jani P, Lacruz RS, Flockerzi V, Kacskovics I, Prakriya M, Feske S: ORAI2 modulates store-operated calcium entry and T cell-mediated immunityNature Communications 8: p. 14714. (2017)

    • József Prechl: A generalized quantitative antibody homeostasis model: regulation of B-cell development by BCR saturation and novel insights into bone marrow function. Clinical & Translational Immunology (2017) 6, e130; doi:10.1038/cti.2016.89
    • József Prechl: A generalized quantitative antibody homeostasis model: antigen saturation, natural antibodies and a quantitative antibody network. Clinical & Translational Immunology (2017) 6, e131; doi:10.1038/cti.2016.90
    • Zsuzsanna Bankó, Judit Pozsgay, Dániel Szili, Mária Tóth, Tamás Gáti, György Nagy, Bernadette Rojkovich, and Gabriella Sármay Induction and Differentiation of IL-10–Producing Regulatory B Cells from Healthy Blood Donors and Rheumatoid Arthritis Patients J. Immunol. 2017; 198:1512-1520.
    • Pozsgay J, Szarka E, Huber K, Babos F, Magyar A, Hudecz F, Sarmay G. Synthetic Peptide-Based ELISA and ELISpot Assay for Identifying Autoantibody Epitopes. Methods Mol Biol. 2016;1352:223-33. doi: 10.1007/978-1-4939-3037-1_17.

    • Pozsgay J, Babos F, Uray K, Magyar A, Gyulai G, Kiss É, Nagy G, Rojkovich B, Hudecz F, Sármay G. In vitro eradication of citrullinated protein specific B-lymphocytes of rheumatoid arthritis patients by targeted bifunctional nanoparticles. Arthritis Res Ther. 2016 Jan 16;18:15. doi: 10.1186/s13075-016-0918-0.

    • Huber K, Sármay G, Kövesdi D. MZ B cells migrate in a T-bet dependent manner and might contribute to the remission of collagen-induced arthritis by the secretion of IL-10. Eur J Immunol. 2016 Sep;46(9):2239-46. doi: 10.1002/eji.201546248.

    • Kecse-Nagy C, Szittner Z, Papp K, Hegyi Z, Rovero P, Migliorini P, Lóránd V, Homolya L, Prechl J Characterization of NF-κB reporter U937 cells and their application for the detection of inflammatory immune-complexes PLOS ONE 11:(5) Paper e0156328. 15 p. (2016)

    • Papp K, Holczer E, Kecse-Nagy C, Szittner Z, Lóránd V, Rovero P, Prechl J, Fürjes P Multiplex determination of antigen specific antibodies with cell binding capability in a self-driven microfluidic system SENSORS AND ACTUATORS B-CHEMICAL 238: pp. 1092-1097. (2017)

    • Szittner Z, Bentlage AE, Rovero P, Migliorini P, Lóránd V, Prechl J, Vidarsson G. Label-free detection of immune complexes with myeloid cells.Clin Exp Immunol. 2016 Jul;185(1):72-80. doi: 10.1111/cei.12788.

    • Orgovan N, Ungai-Salánki R, Lukácsi S, Sándor N, Bajtay Z, Erdei A, Szabó B, Horvath R. Adhesion kinetics of human primary monocytes, dendritic cells, and macrophages: Dynamic cell adhesion measurements with a label-free optical biosensor and their comparison with end-point assays. Biointerphases. 2016 Sep

    • Kremlitzka M, Mácsik-Valent B, Erdei A. Regulation of B cell functions by Toll-like receptors and complement. Immunol Lett. 2016 Oct;178:37-44. doi: 10.1016/j.imlet.2016.07.015.

    • Sándor N, Lukácsi S, Ungai-Salánki R, Orgován N, Szabó B, Horváth R, Erdei A, Bajtay Z. CD11c/CD18 Dominates Adhesion of Human Monocytes, Macrophages and Dendritic Cells over CD11b/CD18. PLoS One. 2016 Sep 22;11(9):e0163120. doi: 10.1371/journal.pone.0163120.

    • Kurucz, I., Peter, B., Prosz, A., Szekacs, I., Horvath, R., & Erdei, A. Label-free optical biosensor for on-line monitoring the integrated response of human B cells upon the engagement of stimulatory and inhibitory immune receptors Sensors and Actuators, B: Chemical, 240, 528-535. DOI: 10.1016/j.snb.2016.09.015

    • Kremlitzka M., Mácsik-Valent B., Polgár A., Kiss E., Poór G., Erdei A. Complement Receptor Type 1 Suppresses Human B Cell Functions in SLE Patients Journal of Immunology Research, vol. 2016, Article ID 5758192, 10 pages, 2016. doi:10.1155/2016/5758192.

    • Erdei A, Sándor N, Mácsik-Valent B, Lukácsi S, Kremlitzka M, Bajtay Z. The versatile functions of complement C3-derived ligands. Immunol Rev. 2016 Nov;274(1):127-140. doi: 10.1111/imr.12498. Review

    • Vince Kornél Grolmusz, Katalin Karászi, Tamás Micsik, Eszter Angéla Tóth, Katalin Mészáros, Gellért Karvaly, Gábor Barna, Péter Márton Szabó, Kornélia Baghy, János Matkó, Ilona Kovalszky, Miklós Tóth, Károly Rácz, Péter Igaz, Attila Patócs.  Cell cycle dependent RRM2 may serve as proliferation marker and pharmaceutical target in
      adrenocortical cancer.
       Am J Cancer Res 2016;6(9):2041-2053
    • Osteikoetxea-Molnár A, Szabó-Meleg E, Tóth EA, Oszvald Á, Izsépi E, Kremlitzka M, Biri B, Nyitray L, Bozó T, Németh P, Kellermayer M, Nyitrai M, Matko J. The growth determinants and transport properties of tunneling nanotube networks between B lymphocytes. Cell Mol Life Sci. 2016 Apr 28. [Epub ahead of print] PMID:27125884

    • Grolmusz VK, Tóth EA, Baghy K, Likó I, Darvasi O, Kovalszky I, Matkó J, Rácz K, Patócs A. Fluorescence activated cell sorting followed by small RNA sequencing reveals stable microRNA expression during cell cycle progression. BMC Genomics. 2016 May 27;17(1):412. doi: 10.1186/s12864-016-2747-6. PMID: 27234232

    • Mészáros T, Csincsi ÁI, Uzonyi B, Hebecker M, Fülöp TG, Erdei A, Szebeni J, Józsi M. Factor H inhibits complement activation induced by liposomal and micellar drugs and the therapeutic antibody rituximab in vitro. Nanomedicine. 2016 May;12(4):1023-31.
    • Schneider AE, Sándor N, Kárpáti É, Józsi M. Complement factor H modulates the activation of human neutrophil granulocytes and the generation of neutrophil extracellular traps. Mol Immunol. 2016 Apr;72:37-48.
    • Schmidt CQ, Harder MJ, Nichols EM, Hebecker M, Anliker M, Höchsmann B, Simmet T, Csincsi ÁI, Uzonyi B, Pappworth IY, Ricklin D, Lambris JD, Schrezenmeier H, Józsi M, Marchbank KJ. Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients. Immunobiology. 2016 Apr;221(4):503-11.
    • Nozal P, Bernabéu-Herrero ME, Uzonyi B, Szilágyi Á, Hyvärinen S, Prohászka Z, Jokiranta TS, Sánchez-Corral P, López-Trascasa M, Józsi M. Heterogeneity but individual constancy of epitopes, isotypes and avidity of factor H autoantibodies in atypical hemolytic uremic syndrome. Mol Immunol. 2016 Feb;70:47-55.
    • Prechl J, Papp K, Herincs Z, Peterfy H, Lorand V, Szittner Z, Estonba A, Rovero P, Paolini I, Del Amo J, Uribarri M, Alcaro MC, Ruiz-Larranaga O, Migliorini P, Czirjak L Serological and Genetic Evidence for Altered Complement System Functionality in Systemic Lupus Erythematosus: Findings of the GAPAID Consortium. PLOS ONE 11:(3) p. e0150685.
  • Új cikkeink 2015-ben
  • Az immunológia tankönyv ingyenesen elérhető
    2015. január
  • ELTE TDK konferencia Helyezettjeink (2014. november 22.):
    • Zöldi Miklós
    • Orosz Anita

    OTDK-ra továbbjutók:

    • Szenes Éva
    • Szikora Bence
    • Lukácsi Szilvia Zsófia
    • Nagy Antal Balázs

    Minden ifjú kollégánknak gratulálunk!!!

Támogatások

Elérhetőség

Cím: 1117 Budapest, Pázmány Péter sétány 1/c
Tel: 06-1-381-2175 FAX: 06-1-381-2176